Matthias Wuttke

Current Position

Junior Group Leader

Academic Education

2000 - 2007	Studies of Human Medicine (M.D.), University of Heidelberg
2000 - 2007	Studies of Computer Science, FernUniversität Hagen

Advanced Qualifications

2003 - 2007

Doctoral degree in medicine (Dr. med.), Biochemie-Zentrum, University of Heidelberg

Postgraduate Positions

2019 - present	Junior Group Leader, Institute of Epidemiology und Prevention, Medical Center - University of Freiburg
2013 - 2018	Postdoctoral Fellow, Institute of Epidemiology und Prevention, Medical Center - University of Freiburg
2008 - present	Meona GmbH (founder, CTO 2008 – present)
2008 - 2013	Nephrology Fellowship, Medical Center - University of Freiburg

Link to all publications of Matthias Wuttke: PubMed

Publications on CRC 1453 funding

Smit RAJ, Wade K, Hui Q, …, Wuttke M, …, Timpson NJ, Hirschhorn JN, Sun YV, Berndt SI, Loos RJF. Polygenic prediction of body mass index and obesity through the life course and across ancestries. Nat Med (2025). Scherer N, Fässler D, Borisov O, Cheng Y, Schlosser P, Wuttke M, …, Sekula P, Hoppmann A, Schultheiss UT, …, Schmidts, Köttgen M, …, Grünert SC, Estrada K, Thiele I, Hertel J, Köttgen A. Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits. Nat Genet (2025). Hoefele J, Eble J, Hermle T, Wuttke M, Schultheiss UT. Extrarenal manifestations in inherited kidney diseases. Nephrol Dial Transplant (2024). Patil S, Borisov O, Scherer N, Wirth C, Schlosser P, Wuttke M, …, Eckardt KU, Hunte C, Neubauer B, Köttgen A, Köttgen M. The membrane transporter SLC25A48 enables transport of choline into human mitochondria. Kidney Int (2024). Rodriguez-Hernandez Z, Gorski M, Tellez-Plaza M, Schlosser P, Wuttke M. metaGWASmanager: a toolbox for an automated workflow from phenotypes to meta-analysis in GWAS consortia. Bioinformatics (2024). Suzuki K, Hatzikotoulas K, Southam L, …, Wuttke M, …, Köttgen A, …, Rotter JI, Vujkovic M, Voight BF, Morris AP, Zeggini E. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature (2024). Scholz M, Horn K, Pott J, Wuttke M, Kühnapfel A, …, Köttgen A, Schlosser P, Pattaro C. X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements. Nat Commun (2024). Riedhammer KM, Nguyen TMT, Kosukcu C, Calzada-Wack J, Li Y, …, Schlosser P, …, Wuttke M, …, Bergmann C, …, Antony D, …, Schell C, …, Köttgen A, Arnold S, Ozaltin F, Schmidts M, Hoefele J. Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT). Kidney Int (2023). Schlosser P, Scherer N, Grundner-Culemann F, Monteiro-Martins S, Haug S, …, Wuttke M, …, Köttgen M, …, Schmidts M, …, Schultheiss UT, …, Sekula P, Li Y, Köttgen A. Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine. Nat Genet (2023). Ghasemi S, Wuttke M. Genetic Association Analysis of Chronic Kidney Disease Progression in a Small Korean Cohort Study. J Am Soc Nephrol (2023). Wuttke M, König E, Katsara MA, Kirsten H, Farahani SK, …, Günzel D, Köttgen A, Fuchsberger C. Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank. Nat Commun (2023). Pfau A, López-Cayuqueo KI, Scherer N, Wuttke M, Wernstedt A, …, Köttgen A, Jentsch TJ, Knauf F. SLC26A1 is a major determinant of sulfate homeostasis in humans. J Clin Invest (2023) Steinbrenner I, Yu Z, Jin J, Schultheiss UT, Kotsis F, …, Wuttke M, …, Chatterjee N, Sekula P, Köttgen A. A polygenic score for reduced kidney function and adverse outcomes in a cohort with chronic kidney disease. Kidney international (2022). Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, …, Wuttke M, …, Köttgen A, …, Wood AR, Visscher PM, Hirschhorn JN. A saturated map of common genetic variants associated with human height. Nature (2022). Yu Z, Wuttke M. Including APOL1 alleles and ancestry adjustments improve a genome-wide polygenic CKD score. Kidney Int (2022). Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, …, Wuttke M, …, Preissl S, …, Köttgen A, …, Rotter JI, McCarthy MI, Morris AP. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet (2022). Li Y, Cheng Y, Consolato F, Schiano G, Chong MR, …, Sekula P, Steinbrenner I, Schlosser P, …, Schultheiss UT, …, Wuttke M, …, Devuyst O, Rampoldi L, Köttgen A. Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases. JCI Insight (2022). KDIGO Conference Participants. Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int (2022). Joseph CB, Mariniello M, Yoshifuji A, Schiano G, Lake J, …, Wuttke M, …, Köttgen A, Hayward C, Devuyst O. Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin. JASN (2022). Stanzick KJ, Li Y, Schlosser P, Gorski M, Wuttke M, …, Köttgen A, Stark KJ, Heid IM, Winkler TW. Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals. Nat Commun (2021). Kotsis F, Schultheiss UT, Wuttke M, Schlosser P, Mielke J, …, Sekula P, Köttgen A, GCKD Investigators. Self-Reported Medication Use and Urinary Drug Metabolites in the German Chronic Kidney Disease (GCKD) Study. J Am Soc Nephrol (2021).